Held in November each year, the National Road Safety Conference is Road Safety GB’s flagship annual event. The conference moves around the country and is hosted and organised each year by a Road Safety GB Regional Group or Groups.

Around 400 people attended NRSC 2023 in the Cotswolds, which in recent years has attracted delegates from across the UK and much further afield including Ireland, Belgium, Trinidad & Tobago, Romania, Australia, Ukraine and the Czech Republic.

Delegates comprise local authority road safety officers, police and fire & rescue officers, central government departments, academics and representatives from other road safety stakeholder organisations in the private and third sectors.

The National Road Safety Conference has previously been held in the following locations:
2009 – Cambridge
2010 - Chesford, Warwickshire
2011 – Chester
2012 – London
2013 – Harrogate
2014 – Brighton
2015 – Nottingham
2016 – Bristol
2017 – Manchester
2018 - Brighton
2019 - Telford
2022 - Harrogate
2023 - The Cotswolds (nr Cirencestor)